Patriots vs Bills Monday Night Football Picks and Predictions: Pats Have Edge in AFC East Clash

After a few ho-hum games on primetime, Monday Night Football in Week 13 features a fantastic matchup between the New England Patriots and Buffalo Bills.

Oddsmakers are expecting a close game between these AFC East rivals that are ranked fourth and sixth respectively in the latest Covers NFL Power Rankings. NFL betting lines opened with the Bills installed as 3-point home favorites before shortening to -2.5. 

Here are our best free Patriots vs. Bills NFL picks and predictions for MNF action on December 6.  

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